Chemistry Faculty Scholarship
Document Type
Article
Publication Date
4-1-2009
Publication Title
Biochim Biophys Acta.
Keywords
lipid droplet; lipolysis; lipogenesis; perilipin; PAT proteins; adipocyte
Abstract
The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose differentiation-related protein (ADRP), tail-interacting protein of 47 kiloDaltons (TIP47), S3-12, and OXPAT. Members of this family are also present in evolutionarily distant organisms, including insects, slime molds and fungi. All PAT proteins share sequence similarity and the ability to bind intracellular lipid droplets, either constitutively or in response to metabolic stimuli, such as increased lipid flux into or out of lipid droplets. Positioned at the lipid droplet surface, PAT proteins manage access of other proteins (lipases) to the lipid esters within the lipid droplet core and can interact with cellular machinery important for lipid droplet biogenesis. Genetic variations in the gene for the best characterized of the mammalian PAT proteins, perilipin, have been associated with metabolic phenotypes, including type 2 diabetes mellitus and obesity. In this review, we discuss how the PAT proteins regulate cellular lipid metabolism both in mammals and in model organisms.
First Page
419
Last Page
440
Repository Citation
Tansey, John, "PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim Biophys Acta" (2009). Chemistry Faculty Scholarship. 15.
https://digitalcommons.otterbein.edu/chem_fac/15
DOI
10.1016/j.bbalip.2009.04.002
Version
Publisher's Version
Peer Reviewed
1
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.