Nursing Student Class Projects (Formerly MSN)

Academic Term

Summer 2022

Document Type


Course Number


Course Name

Advanced Pathophysiology for the Advanced Practice Nurse

Professor’s Name

Dr. Deana Batross and Dr. Shivani Bhatnagar


Aortic Stenosis, Pathogenesis, Pathophysiology, Treatment options, Significance of disease process, Nursing Implications

Subject Categories

Cardiovascular Diseases | Cardiovascular System | Circulatory and Respiratory Physiology | Immune System Diseases | Medical Pharmacology | Medical Physiology | Pathological Conditions, Signs and Symptoms | Physiological Processes


Pathophysiology of Aortic Stenosis

Melissa J. Lee

Department of Nursing, Otterbein University

NURS 6810: Advanced Pathophysiology for the Advanced Practice Nurse

Dr. Deana Batross & Dr. Shivani Bhatnagar

July 29, 2022

Pathophysiology of Aortic Stenosis

Proper evaluation of co-morbidities is imperative for patient safety and successful outcomes for patients undergoing anesthesia. Aortic stenosis (AS) is one of the most complex diseases encountered in anesthesia, affecting five percent of older adults and ten percent of the 80-89-year-old-cohort (Joseph et al., 2017). The pathophysiological development of AS is the end result of an inflammatory process caused by endothelial damage from mechanical stress, accumulation of lipid and calcium deposits, and the subsequent leaflet thickening and valvular narrowing (Joseph et al., 2017). Additionally, myocardial thickening is seen in AS, requiring a compensatory increase in afterload to maintain coronary perfusion (Zheng et al., 2020). Optimization of perioperative risk factors is required to avoid serious intraoperative hemodynamic complications. Understanding the signs and symptoms of disease as well as pathological processes of aortic stenosis is paramount to providing safe and effective anesthetic care based on well-defined hemodynamic goals. The goal of this poster presentation on aortic stenosis is to describe the pathophysiology, symptoms, treatment modalities and considerations for healthcare providers as it relates to the management of these patients.


Joseph, J., Naqvi, S. Y., Giri, J., & Goldberg, S. (2017). Aortic stenosis: pathophysiology, diagnosis, and therapy. The American Journal of Medicine, 130(3), 253–263.

Zheng, K. H., Tzolos, E., & Dweck, M. R. (2020). Pathophysiology of aortic stenosis and future perspectives for medical therapy. Cardiology Clinics, 38(1), 1–12.

Licensing Permission

Copyright, all rights reserved. Fair Use



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