Advanced Pathophysiology for the APN
Dr. Sue Butz & Dr. John Chovan
SARS-CoV-2, Coronavirus Disease 2019, Neurotropism, Neuroinvasion, Long-term Sequelae, CNS
Medical Neurobiology | Nervous System Diseases
Over the last century, science and literature has reported neurological manifestations during various disease outbreaks as well as long-term sequelae following epidemics and pandemics. Some of the first neurological symptoms reported with Coronavirus Disease 2019 (COVID-19; caused by severe acute respiratory syndrome coronavirus 2 [SARS-Cov-2]) were anosmia and dysgeusia, suggesting SARS-CoV-2 penetrance of the central nervous system (CNS). To date, the definite clinical and pathological basis of CNS involvement of SARS-CoV-2 remains poorly understood, with the neurovirulence of SARS-CoV-2 and its neuroinvasive potential remaining largely unknown. The author’s poster will explore neurological manifestations of COVID-19 disease, the direct and indirect pathways responsible for SARS-CoV-2 neuroinvasion, and the specific mechanisms postulated to be responsible for SARS-CoV-2 neurotropism. Ultimately, large-scale studies are needed to correlate neurological manifestations with the neuroinvasion potential and neurovirulence of SARS-CoV-2 (CSF, MRI, postmortem brain studies thus far are limited and evidence to date remains equivocal). COVID-19 vaccination to date appears to prevent severe neurological manifestations, indicating it may prevent future neurological disease; however, the unprecedented amount of misinformation circulating on social media and cable news continues to be a barrier for unvaccinated individuals in the United States.
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Tatusko, Heather M., "Poster: SARS-CoV-2 Neuroinvasion" (2021). Nursing Student Class Projects (Formerly MSN). 472.