Nursing Student Class Projects (Formerly MSN)
ORCID
0009-0004-2429-4784
Academic Term
Summer 2021
Document Type
Project
Course Number
NURS 6810
Course Name
Advanced Pathophysiology for the APN
Professor’s Name
Dr. Sue Butz & Dr. John Chovan
Keywords
SARS-CoV-2, Coronavirus Disease 2019, Neurotropism, Neuroinvasion, Long-term Sequelae, CNS
Subject Categories
Medical Neurobiology | Nervous System Diseases
Abstract
Over the last century, science and literature has reported neurological manifestations during various disease outbreaks as well as long-term sequelae following epidemics and pandemics. Some of the first neurological symptoms reported with Coronavirus Disease 2019 (COVID-19; caused by severe acute respiratory syndrome coronavirus 2 [SARS-Cov-2]) were anosmia and dysgeusia, suggesting SARS-CoV-2 penetrance of the central nervous system (CNS). To date, the definite clinical and pathological basis of CNS involvement of SARS-CoV-2 remains poorly understood, with the neurovirulence of SARS-CoV-2 and its neuroinvasive potential remaining largely unknown. The author’s poster will explore neurological manifestations of COVID-19 disease, the direct and indirect pathways responsible for SARS-CoV-2 neuroinvasion, and the specific mechanisms postulated to be responsible for SARS-CoV-2 neurotropism. Ultimately, large-scale studies are needed to correlate neurological manifestations with the neuroinvasion potential and neurovirulence of SARS-CoV-2 (CSF, MRI, postmortem brain studies thus far are limited and evidence to date remains equivocal). COVID-19 vaccination to date appears to prevent severe neurological manifestations, indicating it may prevent future neurological disease; however, the unprecedented amount of misinformation circulating on social media and cable news continues to be a barrier for unvaccinated individuals in the United States.
Licensing Permission
Copyright, all rights reserved. Fair Use
Recommended Citation
Tatusko, Heather M., "Poster: SARS-CoV-2 Neuroinvasion" (2021). Nursing Student Class Projects (Formerly MSN). 472.
https://digitalcommons.otterbein.edu/stu_msn/472