Advanced Pathophysiology for the Advanced Practice Nurse
Dantrolene, Neuromuscular Blockade, Hypercapnia, Hyper-Metabolic, Anesthesia
Anesthesiology | Physiological Processes
Malignant hyperthermia (MH) is a hypermetabolic response to succinylcholine or inhaled volatile gases administered during anesthesia and is caused by an autosomal dominant mutation of RYR1 or CACNA1S genes which affect how calcium channels function. The uncontrolled, unopposed calcium release and excitation-contraction coupling results in sustained skeletal muscle contraction resulting in muscle rigidity, hyperthermia, hypercapnia, hypertension, and tachycardia among other less common clinical features. The sequelae of an MH crisis include renal failure, rhabdomyolysis, hyperkalemia, metabolic disturbance and left untreated will result in mortality. All clinicians involved in peri-operative care both in-hospital and out of hospital must be cognizant of this potentially lethal complication and respond rapidly with effective, evidence-based care to reduce the likelihood of death. This poster serves to educate healthcare providers, especially anesthesia providers and students, of the pathophysiology, signs and symptoms, and implications on nursing related to malignant hyperthermia.
Copyright, all rights reserved. Fair Use
Jackson, Joel, "Malignant Hyperthermia" (2021). Nursing Student Class Projects (Formerly MSN). 468.