Nursing Student Class Projects (Formerly MSN)
Title
Academic Term
Summer 2021
Document Type
Project
Course Number
NURS 6810
Course Name
Advanced Pathophysiology for the Advanced Practice Nurse
Professor’s Name
Sue Butz
Keywords
Dantrolene, Neuromuscular Blockade, Hypercapnia, Hyper-Metabolic, Anesthesia
Subject Categories
Anesthesiology | Physiological Processes
Abstract
Malignant hyperthermia (MH) is a hypermetabolic response to succinylcholine or inhaled volatile gases administered during anesthesia and is caused by an autosomal dominant mutation of RYR1 or CACNA1S genes which affect how calcium channels function. The uncontrolled, unopposed calcium release and excitation-contraction coupling results in sustained skeletal muscle contraction resulting in muscle rigidity, hyperthermia, hypercapnia, hypertension, and tachycardia among other less common clinical features. The sequelae of an MH crisis include renal failure, rhabdomyolysis, hyperkalemia, metabolic disturbance and left untreated will result in mortality. All clinicians involved in peri-operative care both in-hospital and out of hospital must be cognizant of this potentially lethal complication and respond rapidly with effective, evidence-based care to reduce the likelihood of death. This poster serves to educate healthcare providers, especially anesthesia providers and students, of the pathophysiology, signs and symptoms, and implications on nursing related to malignant hyperthermia.
Licensing Permission
Copyright, all rights reserved. Fair Use
Recommended Citation
Jackson, Joel, "Malignant Hyperthermia" (2021). Nursing Student Class Projects (Formerly MSN). 468.
https://digitalcommons.otterbein.edu/stu_msn/468