Schizophrenia and Genomics

Author

Tiffini Lasch, Otterbein UniversityFollow

Academic Term

Summer 2020

Document Type

Project

Course Number

NURS 6810

Course Name

Advanced Pathophysiology for the Advanced Practice Nurse

Professor’s Name

Dr. Chovan

Keywords

Schizophrenia, Genomics, Gene therapy, Biomarkers, Gene loci

Subject Categories

Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Medicine and Health Sciences | Mental Disorders | Nursing | Psychiatric and Mental Health

Abstract

There are several advancements in genomics under specific categories, such as cancer and autism. Mental health is one of the leading diseases to cause a significant debt burden in today's society. However, genomics has not translated well into mental health treatment. One area of focus is schizophrenia. Those with schizophrenia suffer from severe and devastating symptoms. The symptoms can lead to harsh complications. Which can make it impossible to function in everyday life. Many believe it is not just genetics alone, but also environmental factors that contribute to schizophrenia. Through large genome-wide associated studies, discoveries are being made. There have been discoveries between cognition and schizophrenia to indicate specific biomarkers. Evidence shows that low hippocampal volume can tell researchers there is a rise in ApoC. Testing has shown a correlation between catechol-O-methyltransferase (COMT) DNA methylation, excitement, and depression symptoms of SZ. Researchers are hopeful findings will lead to diagnostic tools and targeting drugs for those who have schizophrenia. Genomics is now part of the Scope and Standards of Practice. To gain the publics respect for the use of genomic steps should be taken before use. Before discussing genomics, clinicians should have a clear understanding of genomics, particularly the limitations. There are many legal and ethical issues to consider. Through education, clinicians can become familiar with genomics and provide the patient with understandable genetic information.

Recommended Citation

Lasch, Tiffini, "Schizophrenia and Genomics" (2020). Nursing Student Class Projects (Formerly MSN). 440.
https://digitalcommons.otterbein.edu/stu_msn/440