Nursing Student Class Projects (Formerly MSN)
Academic Term
Summer 2020
Document Type
Project
Course Number
NURS 6810
Course Name
Advanced Pathophysiology for APN
Professor’s Name
Dr. Butz & Dr. Chovan
Keywords
Malignant Hyperthermia, Anesthesia, Dantrolene, Succinylcholine, Ryanodine receptor
Subject Categories
Medicine and Health Sciences | Nursing
Abstract
Malignant hyperthermia is a rare manifestation of a genetic mutation involving the ryanodine receptors. This mutation causes a sustained intracellular calcium release that is triggered by certain anesthetics such as depolarizing neuromuscular blockers and volatile gases. The extended release of calcium functions as a dangerous catalyst for hyper-metabolism that will lead to rapid death if unrecognized and untreated. Current treatment involves the drug dantrolene in tandem with symptomatic management in the intensive care setting. Symptomatic treatment may likely involve rapid cooling, fluid resuscitation, electrolyte management, and mechanical ventilation until symptoms resolve. A literature review of malignant hyperthermia is of vital importance due to its extreme rarity. Familiarity and competency are correlative. Thus, the more often practitioners receive education on malignant hyperthermia, the more success they will have in treating and preventing death wherever it may occur.
Recommended Citation
Colangelo, Nicholas, "Malignant Hyperthermia" (2020). Nursing Student Class Projects (Formerly MSN). 438.
https://digitalcommons.otterbein.edu/stu_msn/438