Nursing Student Class Projects (Formerly MSN)
Academic Term
Summer 8-1-2016
Document Type
Project
Course Number
N5330
Course Name
Advanced Pathophysiology
Professor’s Name
Dr. Chovan
Keywords
Malignant, hyperthermia, dantrolene, dantrium, anesthesia
Subject Categories
Diseases | Medicine and Health Sciences | Nursing
Abstract
Complications related to the anesthetic process are multifaceted and abundant. As a future nurse anesthesia student, the underlying pathophysiology, diagnosis, and treatment of anesthesia-related complications are of particular interest. One such anesthesia-induced life-threatening metabolic process involves the hypermetabolism of skeletal muscle. This pharmacogenetic process, known as malignant hyperthermia (MH), has a variable incidence rate ranging from 1:10,000 to 1: 250,000 anesthetic cases. However, the prevalence of the genetic abnormalities may be as great as one in 400 individuals (Rosenberg, Pollock, Schiemann, Bulger, & Stowell, 2015, p. 1). “Malignant hyperthermia (MH) is a rare, but life-threatening, autosomal-dominant inherited disorder that may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents, such as volatile anesthetics or depolarizing muscle relaxants” (Schneiderbanger, Johannsen, Roewer, & Schuster, 2014, p. 355).
Recommended Citation
Morriss, Taylor M., "Malignant Hyperthermia" (2016). Nursing Student Class Projects (Formerly MSN). 203.
https://digitalcommons.otterbein.edu/stu_msn/203