Undergraduate Honors Thesis Projects

Date of Award


Document Type

Honors Paper

Degree Name

Biochemistry and Molecular Biology-BS


Biochemistry and Molecular Biology


Dr. John T. Tansey

First Committee Member

Dr. John T. Tansey

Second Committee Member

Dr. Jeffrey Lehman

Third Committee Member

Dr. Cynthia Laurie-Rose


Perilipin 5, Lipase, Colipase, Protein

Subject Categories

Amino Acids, Peptides, and Proteins | Biochemical Phenomena, Metabolism, and Nutrition | Higher Education | Lipids | Medical Biochemistry


Lipid-related disorders have become a point of focus due to the large increase of cases as time has progressed. A common factor of these disorders involves the function of a specific protein family known as the PAT family, which reside on the surface of fat droplets inside of adipose cells. Specifically, Perilipin-5 (PLIN5), a member of the PAT family, is associated with Non-Alcoholic Fatty Liver Disease (NAFLD). The functioning, or lack thereof, of proteins is due to the amino acid sequencing of the proteins and how they are able to interact and dock onto each other. By comparing sequences of PLIN5 from different species, as well as proteins related to PLIN5, differences in sequences of the binding sites of the proteins can show how each protein responds to changes in the protein to which it docks to. Understanding how proteins dock and adapt to changes in each other provides the opportunity to better cater treatment for lipid related disorders.

Licensing Permission

Copyright, all rights reserved. Fair Use

Acknowledgement 2


Available for download on Sunday, April 16, 2028