Undergraduate Honors Thesis Projects
Date of Award
2024
Document Type
Honors Paper
Degree Name
Biochemistry and Molecular Biology-BS
Department
Biochemistry and Molecular Biology
Advisor
Dr. John T. Tansey
First Committee Member
Dr. John T. Tansey
Second Committee Member
Dr. Jeffrey Lehman
Third Committee Member
Dr. Cynthia Laurie-Rose
Keywords
Perilipin 5, Lipase, Colipase, Protein
Subject Categories
Amino Acids, Peptides, and Proteins | Biochemical Phenomena, Metabolism, and Nutrition | Higher Education | Lipids | Medical Biochemistry
Abstract
Lipid-related disorders have become a point of focus due to the large increase of cases as time has progressed. A common factor of these disorders involves the function of a specific protein family known as the PAT family, which reside on the surface of fat droplets inside of adipose cells. Specifically, Perilipin-5 (PLIN5), a member of the PAT family, is associated with Non-Alcoholic Fatty Liver Disease (NAFLD). The functioning, or lack thereof, of proteins is due to the amino acid sequencing of the proteins and how they are able to interact and dock onto each other. By comparing sequences of PLIN5 from different species, as well as proteins related to PLIN5, differences in sequences of the binding sites of the proteins can show how each protein responds to changes in the protein to which it docks to. Understanding how proteins dock and adapt to changes in each other provides the opportunity to better cater treatment for lipid related disorders.
Licensing Permission
Copyright, all rights reserved. Fair Use
Recommended Citation
Saunier, Evan, "Protein-Protein Interaction of Perilipin-5 and Adipose Triglyceride Lipase: A Comparative Study Using Pancreatic Lipase and Colipase" (2024). Undergraduate Honors Thesis Projects. 174.
https://digitalcommons.otterbein.edu/stu_honor/174
Acknowledgement 2
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