Undergraduate Honors Thesis Projects

Date of Award

Spring 4-2024

Document Type

Honors Project

Degree Name

Equine Pre-Veterinary/Pre-Graduate Studies-BS


Equine Science


Dr. Steffanie Burk

First Committee Member

Dr. Steffanie Burk

Second Committee Member

Dr. Jeffrey Lehman

Third Committee Member

Dr. Deborah Solomon


Equine, Parasites, Anthilmentic resistance

Subject Categories

Animal Sciences | Food Science | Higher Education | Large or Food Animal and Equine Medicine | Plant Sciences | Veterinary Medicine | Veterinary Preventive Medicine, Epidemiology, and Public Health | Zoology


Parascaris equorum and Parascaris univalens are two closely related nematodes that infect the respiratory and digestive tracts of equine foals, and cause clinical signs such as coughing, depression, and weight loss. Both Parascaris species have demonstrated resistance to all current anthelmintics, necessitating the search for novel anthelmintics. The aim of this study was to determine if compounds benzyl isothiocyanate (BITC) and papain, present in the seeds of tropical fruit Carica papaya, decrease the motility of L2 Parascaris equorum and Parascaris univalens larvae. Eggs were collected from foal fecal samples, isolated, hatched, and exposed to seven different concentrations (2.0 μg/ml, 10.0 μg/ml, 50 μg/ml, 100 μg/ml, 500 μg/ml, 1000 μg/ml, and 2000 μg/ml) of each compound for 24 hours. Concentrations were tested in triplicate and larval motility was scored before and after exposure. Data were analyzed through linear regression and logarithmic regression, with R2 values of 0.852 (P

Licensing Permission

Copyright, all rights reserved. Fair Use

Acknowledgement 1


Acknowledgement 2


Available for download on Monday, April 17, 2028