Undergraduate Honors Thesis Projects
Date of Award
Spring 4-2024
Document Type
Honors Project
Degree Name
Equine Pre-Veterinary/Pre-Graduate Studies-BS
Department
Equine Science
Advisor
Dr. Steffanie Burk
First Committee Member
Dr. Steffanie Burk
Second Committee Member
Dr. Jeffrey Lehman
Third Committee Member
Dr. Deborah Solomon
Keywords
Equine, Parasites, Anthilmentic resistance
Subject Categories
Animal Sciences | Food Science | Higher Education | Large or Food Animal and Equine Medicine | Plant Sciences | Veterinary Medicine | Veterinary Preventive Medicine, Epidemiology, and Public Health | Zoology
Abstract
Parascaris equorum and Parascaris univalens are two closely related nematodes that infect the respiratory and digestive tracts of equine foals, and cause clinical signs such as coughing, depression, and weight loss. Both Parascaris species have demonstrated resistance to all current anthelmintics, necessitating the search for novel anthelmintics. The aim of this study was to determine if compounds benzyl isothiocyanate (BITC) and papain, present in the seeds of tropical fruit Carica papaya, decrease the motility of L2 Parascaris equorum and Parascaris univalens larvae. Eggs were collected from foal fecal samples, isolated, hatched, and exposed to seven different concentrations (2.0 μg/ml, 10.0 μg/ml, 50 μg/ml, 100 μg/ml, 500 μg/ml, 1000 μg/ml, and 2000 μg/ml) of each compound for 24 hours. Concentrations were tested in triplicate and larval motility was scored before and after exposure. Data were analyzed through linear regression and logarithmic regression, with R2 values of 0.852 (P
Licensing Permission
Copyright, all rights reserved. Fair Use
Recommended Citation
Hickey, Taoni, "Effects of papain and benzyl isothiocyanate on the motility of Parascaris spp. larvae" (2024). Undergraduate Honors Thesis Projects. 168.
https://digitalcommons.otterbein.edu/stu_honor/168
Acknowledgement 1
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