Document Type
Article
Publication Date
1-1-2018
Publication Title
Journal of Medicinal Food
Publisher
Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition
Keywords
Antioxidant, Compound K, Cortisol, Ginsenoside, Inflammation, Muscle Damage, Oxidative Stress
Abstract
The effect of GINST15, an enzyme fermented ginseng supplement, on hormonal and inflammatory responses to physical stress in humans is unknown. The purpose of this investigation was to examine the constitutive and stress-induced effects of GINST15 supplement on hypo-pituitary-adrenal (HPA) and antioxidant activity in addition to muscle damage. Ten women (age: 38.7 ± 7.8 years; height: 163.81 ± 4.4 cm; body mass 76.0 ± 11.6 kg) and nine men (age: 41.2. ± 9.7 years; height: 177.4 ± 5.3 cm; body mass: 88.5 ± 5.0 kg) participated in a double-blinded, placebo-controlled, counterbalanced within-group study. Participants completed three 14-day treatment cycles with different doses (high: 960 mg; low: 160 mg; placebo: 0 mg) separated by a 1-week washout period. At the end of treatment, physical stress was imposed with intense resistance exercise work stress. Participants provided blood at rest and various time points after exercise (immediately [IP], 30 min [30], 60 min [60], 24 h [+24HR]). Cortisol (CORT), superoxide dismutase (SOD), total glutathione, nonspecific antioxidant activity, total antioxidant power (TAP), and creatine kinase were measured. GINST15 supplementation produced stress-inducible dose-dependent reductions in circulating cortisol and increased enzymatic and nonspecific antioxidant activity. Twenty-four hours after intense exercise, a high dose GINST15, a bioactive ginsenoside metabolite, significantly reduces muscle damage and HPA responses to physical stress in humans; these effects may result from increased antioxidant expression.
First Page
104
Last Page
112
Volume
21
Issue
1
Repository Citation
Flanagan, Shawn D.; DuPont, William H.; Caldwell, Lydia K.; Hardesty, Vincent H.; Barnhart, Emily C.; Beeler, Matthew K.; Post, Emily M.; Volek, Jeff S.; and Kraemer, William J., "The Effects of a Korean Ginseng, GINST15, on Hypo-Pituitary-Adrenal and Oxidative Activity Induced by Intense Work Stress" (2018). Health and Sport Sciences Faculty Scholarship. 39.
https://digitalcommons.otterbein.edu/hsports_fac/39
Original Citation
Flanagan SD, DuPont WH, Caldwell LK, Hardesty VH, Barnhart EC, Beeler MK, Post EM, Volek JS, Kraemer WJ. The Effects of a Korean Ginseng, GINST15, on Hypo-Pituitary-Adrenal and Oxidative Activity Induced by Intense Work Stress. J Med Food. 2018 Jan;21(1):104-112. doi: 10.1089/jmf.2017.0071. Epub 2017 Oct 5. PMID: 28981384.
DOI
10.1089/jmf.2017.0071
Peer Reviewed
1
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.