Master of Science in Nursing (MSN) Student Scholarship

Date Written

Summer 2015

Document Type


Course Number

NURS 5330

Course Name

Advanced Pathophysiology

Professor’s Name

John D. Chovan, James R. Cacchillo


Chronic Liver Disease, Fatty Liver Disease, Hyperlipidemia

Subject Categories

Digestive System Diseases | Medical Pathology | Medicine and Health Sciences | Nursing


Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease which refers to the presence of hepatic steatosis without significant intake of alcohol. Non-alcoholic fatty liver disease develops in a variety of forms from reversible simple steatosis to non-alcoholic steatohepatitis (NASH), which if left unchecked can progress to liver fibrosis, cirrhosis and even develop into hepatocellular carcinoma (Mells et al., 2014). NAFLD is thought to be nonthreatening, but with progression over several years could lead to NASH. A strong link between obesity and NASH has been shown. In addition to obesity, insulin resistance (type II diabetes mellitus), and hyperlipidemia all common components of metabolic syndrome, is frequently associated with NAFLD (Nseiri, Mograbi, & Ghali, 2012). If NAFLD goes undetected and progresses, steatohepatitis a serious inflammation of the liver can occur. Steatosis is a term used to describe any condition that allows fat to deposit within the interstitial spaces of an organ. Steatohepatitis comes in two forms. alcohol-related and non-alcoholic related. The distinction of hepatic steatosis lays in excessive alcohol consumption verses little to no alcohol consumption.



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