Master of Science in Nursing (MSN) Student Scholarship

Date Written

Summer 2015

Document Type


Course Number

NURS 5330

Course Name

Advanced Pathophysiology

Professor’s Name

John D. Chovan, James R. Cacchillo


Infections, Sepsis-induced Organ Dysfunction

Subject Categories

Bacterial Infections and Mycoses | Medical Pathology | Medicine and Health Sciences | Nursing


Sepsis is a life-threatening and complicated host response to the presence of infection that is affecting millions of individuals around the world each year (Dellinger et al., 2013, p. 583). According to Gray et al. (2013), sepsis is not only one of the primary causes of hospital admission but it is also a leading cause of morbidity and mortality worldwide (p. 397). Severe sepsis and septic shock are the more advanced and detrimental stages of sepsis, which are starting to increase in incidence and are killing one in four (and sometimes more) individuals infected (Dellinger et al., 2013, p. 583). Dellinger et al. (2013) believes that “the speed and appropriateness of therapy administered in the initial hours after severe sepsis develops are likely to influence outcomes” (p. 583). Additionally, Cawcutt and Peters (2014) were consistent with Dellinger’s findings and explained how early evaluation and appropriate management will significantly reduce the extent of morbidity and mortality related to severe sepsis and septic shock (p. 1572). Thus, it is essential that healthcare professionals, especially those in an intensive care unit (ICU), have extensive knowledge regarding sepsis and how it inevitably can progress to septic shock, and eventually death.



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