Nursing Student Class Projects (Formerly MSN)

Academic Term

Summer 2015

Document Type


Course Number

NURS 5330

Course Name

Advanced Pathophysiology

Professor’s Name

John D. Chovan, James R. Cacchillo


Septic Shock, Organ Failure

Subject Categories

Bacterial Infections and Mycoses | Medical Pathology | Medicine and Health Sciences | Nursing


The current definition of sepsis is suspected or documented infection plus at least one systemic manifestation of infection. Severe sepsis has been defined as sepsis plus evidence of organ dysfunction. Identifying acute organ dysfunction is a marker of severe sepsis. This topic was chosen after witnessing a number a patients fall into septic shock before severe sepsis was diagnosed and treatment initiated. Diagnosis of severe sepsis is important for specific protocol to be implemented in a timely fashion. The current differentiation between sepsis and severe sepsis is evidence of organ dysfunction. There are many examples of organ dysfunction that are not commonly considered when doing a patient workup. Increasing knowledge of acute organ dysfunction markers could potentially lead to earlier diagnosis of severe sepsis. The earlier it is diagnosed, the sooner treatment protocol can be initiated. Recent research showed that if severe sepsis is diagnosed timely, administration of timely drugs improved cardiovascular performance, lessened the inflammatory response, tissue hypo-perfusion and multi-organ injury, and most importantly reduced mortality (Lin, Lee, & Wu, 2013).



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.