Nursing Student Class Projects (Formerly MSN)

Academic Term


Document Type


Course Number

NURS 6810-O1

Course Name

Advanced Pathophysiology for the Advanced Practice Nurse

Professor’s Name

Deana Batross, DNP and Shivani Bhatnagar, DNP


Malignant Hyperthermia, Dantrolene, Volatile Anesthetics, Succinylcholine, Triggering Agents, RYR1 mutation

Subject Categories

Medicine and Health Sciences | Nursing | Perioperative, Operating Room and Surgical Nursing



Malignant Hyperthermia (MH) is a rare inherited disorder in which exposure to triggering agents such as volatile anesthetics or depolarizing neuromuscular blockers causes a hypermetabolic reaction leading to patient fatality. MH susceptible patients have a genetic mutation on the ryanodine one receptor (RYR1) in skeletal muscle, allowing uninhibited calcium release (Smith, Tranovich, & Ebraheim, 2018). Increases in free calcium result in an uncontrollable sustained muscle contraction through the excitation-contraction coupling of myosin and actin. Sustained muscle contraction rapidly consumes adenosine triphosphate stores and stimulates conversion to lactate producing anaerobic metabolism (Smith et al., 2018). Immediate recognition and treatment of MH are warranted to prevent patient fatalities. It is imperative that nurse anesthetists and all perioperative staff understand and can recognize the manifestations and treatment of MH. As a collaborative and well-versed team, perioperative staff can decrease the number of patient fatalities due to Malignant Hyperthermia.

Licensing Permission

Copyright, all rights reserved. Fair Use



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