Nursing Student Class Projects (Formerly MSN)

Academic Term

Summer 8-5-2022

Document Type


Course Number

NURS 6810-01

Course Name

Advanced Pathophysiology for the Advanced Practice Nurse

Professor’s Name

Batross and Bhatnagar


Malignant, Hyperthermia, Calcium, Ryanodine Receptors, Dantrolene

Subject Categories

Medicine and Health Sciences | Nursing


Being a proficient anesthesia provider requires vigilantly monitoring for any complications that may arise during the anesthetic period. Malignant Hyperthermia (MH) is one such complication. Succinylcholine, a neuromuscular blocking agent, and volatile anesthetic gases can initiate an MH reaction. In MH, ryanodine receptors are stimulated to release excess calcium, which causes muscle hypermetabolism. This process causes the patient to develop highly elevated temperatures, hypoxia, hypercarbia, and muscle rigidity. Left untreated, MH can be fatal. Treatment requires discontinuation of the triggering agent, administering dantrolene, providing 100% oxygen, and managing complications such as acidosis, hyperkalemia, and arrhythmias. MH is a manageable complication related to anesthesia of which providers must be aware.

Keywords: malignant hyperthermia, ryanodine receptors, calcium, dantrolene

Licensing Permission

Copyright, some rights reserved. Attribution – Noncommercial – No Derivative Works

Included in

Nursing Commons



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