Advanced Pathophysiology for the Advanced Practice Nurse
Batross and Bhatnagar
Malignant, Hyperthermia, Calcium, Ryanodine Receptors, Dantrolene
Medicine and Health Sciences | Nursing
Being a proficient anesthesia provider requires vigilantly monitoring for any complications that may arise during the anesthetic period. Malignant Hyperthermia (MH) is one such complication. Succinylcholine, a neuromuscular blocking agent, and volatile anesthetic gases can initiate an MH reaction. In MH, ryanodine receptors are stimulated to release excess calcium, which causes muscle hypermetabolism. This process causes the patient to develop highly elevated temperatures, hypoxia, hypercarbia, and muscle rigidity. Left untreated, MH can be fatal. Treatment requires discontinuation of the triggering agent, administering dantrolene, providing 100% oxygen, and managing complications such as acidosis, hyperkalemia, and arrhythmias. MH is a manageable complication related to anesthesia of which providers must be aware.
Keywords: malignant hyperthermia, ryanodine receptors, calcium, dantrolene
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Joos, Jessica, "Malignant Hyperthermia" (2022). Nursing Student Class Projects (Formerly MSN). 497.