Nursing Student Class Projects (Formerly MSN)

Academic Term


Document Type


Course Number

NURS 6810

Course Name

Advanced Pathophysiology for APN

Professor’s Name

Dr. John Chovan


Malignant Hyperthermia, Dantrolene, General Anesthesia, Triggering agents, Skeletal muscle, RYR1 Gene

Subject Categories

Medicine and Health Sciences | Nursing


Malignant Hyperthermia as defined by the International Classification of Diseases is a rare but progressive, and life-threatening hyperthermic reaction in response to a triggering agent such as general anesthetic gases or the depolarizing neuromuscular blocking agent Succinylcholine (Hopkins et. al., 2020). MalignantHyperthymia is a genetic disorder of the skeletal muscle, that leads to continuous muscle contraction and the inability to relax skeletal muscle (Haili and Weant, 2021). Signs and symptoms can vary from patient to patient and can be masked by anesthesia, but the classical signs include an increase in end-tidal CO2, increased heart rate, and a rapid increase in body temperature (Yang et. al., 2020). The treatment includes administering Dantroleneaccording to guidelines and providing supportive care (Gupta and Hopkins, 2017). Prompt recognition and intervention are critical to decreasing mortality and preventing further complications (Gupta and Hopkins,2017). Awareness and education for anesthesia and other health care providers is important in preventing and treating this fatal disease process. This poster provides an in-depth explanation of the pathophysiology, signs and symptoms, treatments, and complications useful for the purpose of educating and spreading awareness for the disease Malignant Hyperthermia

Licensing Permission

Copyright, some rights reserved. Attribution – Noncommercial – Share Alike

Included in

Nursing Commons



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