Nursing Student Class Projects (Formerly MSN)

Academic Term

Fall 2014

Document Type


Course Number

NURS 5330

Course Name

Advanced Pathophysiology

Professor’s Name

John D. Chovan, James R. Cacchillo


Case Study, Skin Diseases

Subject Categories

Immune System Diseases | Medical Pathology | Nursing | Skin and Connective Tissue Diseases


Steven-Johnson’s Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are both diseases mediated by hypersensitive immune reactions resulting in “full thickness epidermal necrosis” characterized by skin detachment. However, in SJS, there is only 10% skin surface area involvement whereas in TEN, over 30% of the skin becomes detached. TENS has a 50% mortality rate. (East-Innis & Thompson, 2013, p. 590) Why Chosen: SJS/TEN is a rare but extremely fatal disease. Initially, it is often mistaken as a simple allergic reaction to a new medication or environmental exposure because both cause truncal rashes and fevers. However, simple allergic reactions occur within days of exposure versus SJS/TEN, which will not mount signs and symptoms until one to three weeks after initial exposure; Meaning it is a delayed hypersensitivity reaction. (Cooper, 2012, p. 54)



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