Nursing Student Class Projects (Formerly MSN)

Academic Term

Summer 2020

Document Type


Course Number

NURS 6810

Course Name

Advanced Pathophysiology

Professor’s Name

Dr. Chovan


Malignant, Hyperthermia, Hypermetabolic, Ryanodine, Mortality

Subject Categories

Critical Care Nursing | Medicine and Health Sciences | Nursing


Malignant hyperthermia (MH) is a condition in which the body goes into a hypermetabolic state affecting skeletal muscle in response to receiving inhaled anesthetics or the neuromuscular blocking agent, succinylcholine. MH is an autosomal dominant disorder that is most closely related to a defect in the ryanodine receptor. The defective receptor causes a rapid increase of intracellular calcium causing hyperthermia, tachycardia, tachypnea, hypercapnia, increased oxygen consumption, acidosis, hyperkalemia, muscle rigidity, and rhabdomyolysis. With the complexity of this disorder and its unique pathophysiological process it is crucial that all parts of the surgical team, especially anesthesia providers, understand how to treat a patient with MH. Certified registered nurse anesthetists (CRNA) serve as anesthesia providers and are responsible for monitoring patients very closely. Clinical signs of MH must be recognized and treated early in order to decrease morbidity and mortality. Future anesthesia providers must be educated on MH as their skill set can determine the fate of a patient.

Keywords: malignant, hyperthermia, ryanodine, hypermetabolic, pathophysiology, mortality



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