Advanced Pathophysiology for the Advanced Practice Nurse
John Chovan PhD, DNP, RN, APRN-CNP, APRN-CNS, Sue Butz DNP, RN, CCRN-K
Sepsis, Pathophysiology, Septic Shock, Infection
Medicine and Health Sciences | Nursing
Sepsis is a life threatening emergency and it is the body’s extreme response to an infection (CDC, 2019). Sepsis continues to be a problem for all medical institutions globally due to its high mortality rate. Sepsis can be caused by any pathogen and may arise from pneumonia, urinary tract infections and infections in the skin or soft tissue (Nagalingam, 2018). As sepsis progresses, it can lead to organ dysfunction, tissue damage and death. The progression of sepsis can be categorized in 3 stages, that is Systemic Inflammatory Response Syndrome (SIRS), severe sepsis and septic shock. Septic shock is the most serious stage and has a mortality rate as high 50% (Ryding, 2018). Time is an important factor in managing sepsis, early recognition and early initiation of treatment impacts the survival rates of sepsis patients.
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