Nursing Student Class Projects (Formerly MSN)

Document Type


Course Number


Course Name

Advanced Pathophysiology

Professor’s Name

Dr. Chovan

Subject Categories

Medicine and Health Sciences | Nursing



Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are two forms of polycystic kidney disease (PKD) and are leading causes of end stage renal disease (Silverman, 2015). PKD can affect both children and adults and is one of the most common hereditary disorders (Silverman, 2015). A mutation on the genes PKD-1 and PKD-2 and the encoding proteins polycystin-1 and polycystin-2 is the pathophysiology behind development of PKD (Silverman, 2015). Genetic testing, renal ultrasounds, CT scans and MRI’s can all be used to help diagnosis PKD (Silverman, 2015). PKD can cause other medical complications like hypertension, cardiac disease, and cerebral aneurysms (Silverman, 2015). Along with renal cyst, cyst formation can occur on other organs such as liver, pancreas, spleen and thyroid (Silverman, 2015). Blood pressure control, exercise, low-salt diet and high water intake should be encouraged to patients with PKD (Tran et al. 2017) Symptom and pain control are important to help manage the disease including infection treatment from UTI’s, bed rest during gross hematuria, and pain analgesics for severe discomfort (Silverman, 2015). Currently no cure exists for PKD, though treatments for symptoms, secondary medical conditions, undergoing dialysis and kidney transplants are used to manage the disease (Silverman, 2015).

Included in

Nursing Commons



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