Dr. John Chovan, PhD., DNP, RN, CNP, CNS
Lynch Syndrome, Colorectal Cancer, Genetics, Hereditary Non-polyposis Colorectal Cancer Syndrome
Medicine and Health Sciences | Nursing
Lynch syndrome (LS) was previously known as Hereditary Non-polyposis colorectal cancer syndrome (HNPCC) (Shulman, 2015) is a hereditary cancer syndrome. The research explored Lynch Syndrome, the identification, and treatment. Lynch syndrome is associated with cancers of the ovary, stomach, urothelial tract, and small bowel, and less frequently, cancers of the brain, biliary tract, pancreas, and prostate. (Cox et al., 2018) “An individual’s lifetime risk for developing colorectal cancer (CRC) estimated at 5% to 6%; an individual with Lynch syndrome has an 80% lifetime risk. Lynch syndrome is an autosomal dominant disorder caused by germline mutations in 1 of 4 mismatch repair (MMR) genes: MLH1, MSH2, MSH6, and PMS2” (Harrison & Handley, 2017, p. 48) Individual monitoring and preventative care is key to early detection and treatment.
Nutter, Raejeanne B., "Lynch Syndrome" (2018). Master of Science in Nursing (MSN) Student Scholarship. 331.