Dr. John Chovan, PhD., DNP, RN, CNP, CNS
Crohn's Disease, Autoimmune Disease, Pthophysiology of Crohn's Disease, Mucosal Immune System, Inflammatory Bowel Disease
Medicine and Health Sciences | Nursing
Crohn’s disease is a progressive and systemic autoimmune disease that causes inflammation to any part of the gastrointestinal tract. The inflammation causes some of the clinical manifestations of crohn’s disease such as abdominal pain, diarrhea, malnutrition, weight loss and fatigue. The cause of crohn’s disease is unknown; however, studies show genetic predisposition, environmental exposures and the gastrointestinal tract microbiome playing roles in the development of crohn’s disease. Crohn’s disease involves the abnormal response of the immune system or a malfunctioning of mucosal immune system to offensive microorganisms which leads to gastrointestinal tissue injury.
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