Master of Science in Nursing (MSN) Student Scholarship

Date Written

Summer 8-1-2016

Document Type


Course Number


Course Name

Advanced Pathophysiology

Professor’s Name

Dr. Chovan


Malignant, hyperthermia, dantrolene, dantrium, anesthesia

Subject Categories

Diseases | Medicine and Health Sciences | Nursing


Complications related to the anesthetic process are multifaceted and abundant. As a future nurse anesthesia student, the underlying pathophysiology, diagnosis, and treatment of anesthesia-related complications are of particular interest. One such anesthesia-induced life-threatening metabolic process involves the hypermetabolism of skeletal muscle. This pharmacogenetic process, known as malignant hyperthermia (MH), has a variable incidence rate ranging from 1:10,000 to 1: 250,000 anesthetic cases. However, the prevalence of the genetic abnormalities may be as great as one in 400 individuals (Rosenberg, Pollock, Schiemann, Bulger, & Stowell, 2015, p. 1). “Malignant hyperthermia (MH) is a rare, but life-threatening, autosomal-dominant inherited disorder that may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents, such as volatile anesthetics or depolarizing muscle relaxants” (Schneiderbanger, Johannsen, Roewer, & Schuster, 2014, p. 355).



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