Master of Science in Nursing (MSN) Student Scholarship

Date Written

Summer 8-4-2016

Document Type


Course Number

N 5330

Course Name

Advanced Pathophysiology

Professor’s Name

Dr. Chovan


pseudocholinesterase deficiency, muscle paralysis, peripheral nerve stimulator, succinycholine

Subject Categories

Medicine and Health Sciences | Nursing


Pseudocholinesterase is an enzyme produced in the liver that metabolizes neuromuscular blocking agents, particularly succinylcholine. A deficiency in pseudocholinesterase is typically caused by either a homozygous or heterozygous abnormal genetic variant of the enzyme which leads to a prolonged neuromuscular block and therefore muscle paralysis. It is vital for anesthesia providers to know the mechanism of action and duration of succinylcholine, as well as appropriate assessment and treatment if a pseucholinesterase deficiency is suspected. There is no treatment for a pseudocholinesterase deficiency of a genetic origin, however supportive care, particularly ventilator support, must be provided until the medication has been adequately metabolized and the patient has regained muscle strength as evidenced by adequate ventilatory effort and four strong twitches without fade when stimulated by a peripheral nerve stimulator (Stoelting & Hiller, 2015)

Included in

Nursing Commons



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