Master of Science in Nursing (MSN) Student Scholarship

Date Written


Document Type


Course Number

NURS 5330

Course Name

Advanced Pathophysiology

Professor’s Name

Dr. John Chovan


Lupus Nephritis, Pathophysiology, Management, Implications, Lupus

Subject Categories

Medicine and Health Sciences | Nursing


Systemic Lupus Erythematosus (SLE) can be described as a chronic, complex, autoimmune disorder (McCance & Huether, 2014). Disproportionately affecting women, and those of Afro-Cuban, Hispanic, Asian, and American Indian descent, SLE has a prevalence of 2.0 to 7.6 cases per 100,000 persons in the United States. Characterized by chaotic autoantibody production, complement alterations, and formation of immune complexes, SLE has the potential to generate devastating damage to multiple organ systems. Formed from the binding of autoantibodies and self-antigens, immune complexes often result in renal damage, a significant complication of the disease. Through careful analysis and synopsis of literature, the writer intends to provide the audience with pathophysiologic concepts defining lupus nephritis (LN). Within ten years of SLE diagnosis, between 50% and 60% of adults diagnosed will go on to develop LN (Richey, 2014). Of those with LN, upwards of 17% will go on to develop end stage renal disease (Bose, Silverman, & Bargman, 2014). The devastating course of this condition prompted the writer’s choice of LN as a topic of interest for the purpose of this project, as she wished to gain valuable knowledge regarding the ailment and implications for advanced nursing practice.

Included in

Nursing Commons



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