Master of Science in Nursing (MSN) Student Scholarship

Date Written

Summer 7-27-2016

Document Type


Course Number

NURS 5330

Course Name

Advanced Pathophysiology

Professor’s Name

Dr. Chovan


Malignant hyperthermia, Dantrolene, Anesthesia complication, Operating room, Volatile anesthetics, Succinylcholine

Subject Categories

Medicine and Health Sciences | Nursing


Providing patient care in the operating room as a nurse anesthetist is rewarding and challenging. There is a paramount level of responsibility that lies on certified registered nurse anesthetist (CRNA). Recognition of serious life threatening conditions by CRNA must be prompt and treated urgently. As a student registered nurse anesthetist and future CRNA, knowing how to recognize and treat developed emergency conditions while patient is under anesthesia or recovering from anesthesia is an absolute requirement. Malignant hyperthermia (MH), is a rare autosomal dominant hypermetabolic life threatening disorder of skeletal muscle. Malignant hyperthermia is caused by volatile anesthetics (desflurane, sevoflurane, isoflurane) or depolarizing muscle relaxant (succinylcholine). Incidence of MH varies between 1/50,000 to 1/250,000 and highest in young population with average age of 18.3 years upon exposure to volatile anesthetics or succinylcholine and is associated with 23 genetic mutations.

Included in

Nursing Commons



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