Master of Science in Nursing (MSN) Student Scholarship

Date Written

Summer 7-15-2016

Document Type


Course Number


Course Name

Advanced Pathophysiology

Professor’s Name

Dr Chovan


Malignant Hyperthermia, RyR1 Mutation, Critical Care, Anesthesia, Nursing, Pathophysiology

Subject Categories

Anesthesiology | Critical Care Nursing | Medical Pathology | Medical Physiology | Medicine and Health Sciences | Nursing


Malignant hyperthermia is a rare disease trait and can take place in a variety of settings. If not treated in a timely manner, the consequences will be dire. It is recommended that nurses and other healthcare personnel be properly educated on MH crises. By detecting the signs and symptoms associated with the disease, providers can efficiently remedy the crisis and save patient lives (Seifert, 2014). Since the discovery of dantrolene in 1975 and the advancement of genetics regarding MH, death rates dropped from about 80% to about 5% (Schneiderbanger et al., 2014). Today there is a MH group called the Malignant Hyperthermia Association of the United States which offers education and support for victims of MH. There is also a 24-hour hotline for people to call during an MH emergency (Dirksen et al., 2013).



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