Date Written

Spring 3-20-2018

Document Type

Honors Paper

Degree Name

Biochemistry and Molecular Biology-BS

Department

Chemistry

Advisor

Dr. Robin Grote

First Committee Member

Dr. John Tansey

Second Committee Member

Dr. Carrigan Hayes

Keywords

Heterocycle, Medicinal Chemistry, Electron Withdrawing Groups

Subject Categories

Biochemistry | Chemistry | Organic Chemistry

Abstract

The given research will investigate synthetic strategies and differential functionalization of 1,3,4- oxadiazoles in hopes of obtaining moderate to high yields. Particularly, the effects of electron withdrawing on oxadiazoles will reveal more information about possible mechanistic details and reaction optimization.

The research in this report is a part of a lager research effort being investigated by Dr. Robin Grote. This research is ongoing and has evolved from its start in the Grote Lab. Previously, the Grote Lab has focused on the formation of a patented heterocycle that contained an amino-pyrazine functional group. Currently, our research has shifted focus to the formation of a more general heterocycle that contains two phenyl R-groups with various electron withdrawing and electron donating groups. By changing our target 1,3,4 oxadiazole it has allowed the Grote research to go from a very specific molecule with limited uses to a broader molecule that has more potential for a biological scaffold.

Available for download on Monday, April 06, 2020

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