Undergraduate Honors Thesis Projects
Investigating The Synthesis of 1,3,4-Oxadiazoles Via a Novel Two-Step-One-Pot Cyclodehydration Reaction
Date of Award
Biochemistry and Molecular Biology-BS
Dr. Robin Grote
First Committee Member
Dr. John Tansey
Second Committee Member
Dr. Carrigan Hayes
Heterocycle, Medicinal Chemistry, Electron Withdrawing Groups
Biochemistry | Chemistry | Organic Chemistry
The given research will investigate synthetic strategies and differential functionalization of 1,3,4- oxadiazoles in hopes of obtaining moderate to high yields. Particularly, the effects of electron withdrawing on oxadiazoles will reveal more information about possible mechanistic details and reaction optimization.
The research in this report is a part of a lager research effort being investigated by Dr. Robin Grote. This research is ongoing and has evolved from its start in the Grote Lab. Previously, the Grote Lab has focused on the formation of a patented heterocycle that contained an amino-pyrazine functional group. Currently, our research has shifted focus to the formation of a more general heterocycle that contains two phenyl R-groups with various electron withdrawing and electron donating groups. By changing our target 1,3,4 oxadiazole it has allowed the Grote research to go from a very specific molecule with limited uses to a broader molecule that has more potential for a biological scaffold.
Sowers, Brittney, "Investigating The Synthesis of 1,3,4-Oxadiazoles Via a Novel Two-Step-One-Pot Cyclodehydration Reaction" (2018). Undergraduate Honors Thesis Projects. 63.