Date Written


Document Type

Honors Paper

Degree Name

Biochemistry and Molecular Biology-BS


Biochemistry and Molecular Biology


John Tansey, Ph.D.

First Committee Member

John Tansey, Ph.D.

Second Committee Member

Jennifer Bennett, Ph.D.

Third Committee Member

Stephanie Patridge, Ph.D.


Lipid Metabolism, Evolution, Bioinformatics, CGI-58, ATGL, Perilipin

Subject Categories

Bioinformatics | Other Biochemistry, Biophysics, and Structural Biology


Lipolysis is a conserved pathway used by organisms for the mobilization of fatty acid (FA) out of triacylglycerol (TAG). Neutral lipids are stored in lipid-storage droplets (LSD) which are in nearly every cell of an organism. LSDs are the location of lipolysis. Perilipin proteins are lipid-droplet associated proteins. Perilipins interact with other proteins such as ATGL that breaks down TAG into FA and DAG. Because of its conservation as a whole system, this suggests that proteins of the same pathway are evolving together. This present study traces the evolutionary history of lipolysis-related proteins amongst individual organisms and classes of organisms to look at the conservation of relationship between the proteins.

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