ORCID

A20121397

Date of Award

Summer 5-3-2026

Document Type

Project

Degree Name

Doctor of Nursing Practice (DNP)

Department

Nursing

Advisor

Brian Garrett, DNP, CRNA

First Committee Member

Danielle Winch, DNP, CRNA

Second Committee Member

Amy Bishop, DNP, AGCNS-BC

Third Committee Member

John Chovan, PhD, DNP, RN, CNP, CNS, PMHNP-BC, PMHCNS-BC

Keywords

Remimazolam Tosilate, Propofol, Monitored Anesthesia Care, Elderly Patients, Hemodynamic stability, Endoscopic Procedures

Subject Categories

Medicine and Health Sciences

Abstract

Endoscopic procedures are essential for diagnosing and managing gastrointestinal conditions, particularly in a growing elderly population. The selection of sedative agents significantly influences patient safety and procedural outcomes. Propofol, the traditional choice, is successful but associated with risks such as hypotension, bradycardia, and respiratory depression, particularly in elderly patients. This hypothetical Doctor of Nursing Practice (DNP) project explores the use of remimazolam tosilate (RT), a novel ultra-short-acting benzodiazepine, as an alternative to propofol during monitored anesthesia care (MAC) for elderly patients undergoing endoscopic procedures. The project utilizes a randomized controlled trial (RCT) design to compare RT and propofol regarding hemodynamic stability, respiratory outcomes, recovery times, and patient satisfaction. The project team collects quantitative data via validated tools, including the Modified Observer’s Assessment of Alertness/Sedation Scale and Aldrete Scoring System, and gathers qualitative feedback through Likert-scale surveys. Findings highlight that RT maintains superior hemodynamic stability, reduces respiratory complications, and achieves comparable sedation success with shorter recovery times than propofol. These results suggest that RT is safer and more optimal for elderly patients, aligning with evidence-based practice goals to enhance patient outcomes and procedural efficiency. By addressing the limitations of traditional sedatives, this project underscores the potential of RT to improve clinical practices in geriatric anesthesia care. Future implementation of RT protocols could enhance patient safety, reduce healthcare costs, and optimize resource utilization.

Acknowledgement 1

1

Acknowledgement 2

1

Licensing Permission

Copyright, all rights reserved. Fair Use

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.