John D. Chovan, James R. Cacchillo
Hemic and Lymphatic Diseases | Medical Pathology | Nursing
Lymphedema is a disfiguring condition whose hallmark is progressive, increasing swelling which occurs as a result of the accumulation of protein rich fluid in interstitial spaces. Those individuals who are affected suffer from either primary lymphedema or secondary lymphedema; the pathophysiology of both conditions is similar. Lymphedema can be a chronic, acute, or transient alteration, which can eventually lead to keratinization of the skin. An increase in the incidence of lymphedema has also been observed with increase in levels of obesity.
Cruz, Bernadine, "Lymphedema: Pathophysiology, Diagnosis & Management" (2014). Master of Science in Nursing (MSN) Student Scholarship. Paper 9.