John D. Chovan, James R. Cacchillo
Lung Diseases, Case Studies, Anti-neutrophil Cytoplasmic Antibodies
Medical Pathology | Medicine and Health Sciences | Nursing | Respiratory Tract Diseases
The exact cause of GPA has yet to be identified. Dinić et al. (2013) defines GPA/WG as “anti-neutrophil cytoplasmic antibodies (ANCAs)- associated systemic vasculitis of unknown etiology” (p. 887). According to Alam, Dastider, Ahmed, and Rabbani (2012) both cellular and humoral immunity are thought to be involved in the pathogenesis of wegener’s granulomatosis. “ The initial pathologic lesion is granuloma believed to be caused by cellular immune process. The strong association on C-ANCA with this disease suggests the role of humoral immunity” (Alam et al., 2014, p. 98). Huang et al. (2013) suggest, “The main pathological features of limited Wegeners’ in the lung including liquefaction and coagulation necrosis lesions, as well as large number of eosinophils, and a small amount of lymphoplasmacytic infiltration, the destructive vasculitis can be found in the small pulmonary arties and veins”(p. 5). Some believe that environmental factors, such as dust inhalation, is related to the cause, but this is only seen in about 10% of patients with GPA (Cornarmond & Cacoub, 2014). Also, it has been suggested that infectious agents, such as Staphylococcus aureus in the nasal carriage, may play a role in triggering the disease, particularly though a mechanism of molecular mimicry (Cornarmond & Cacoub, 2014).
Palumbo, Dawn, "Granulomatosis with Polyangiitis (Wegner’s) : Often Mistaken for Tuberculosis" (2015). Master of Science in Nursing (MSN) Student Scholarship. Paper 87.