Master of Science in Nursing (MSN) Student Scholarship

Date Written

Summer 2015

Document Type

Project

Course Number

NURS 5330

Course Name

Advanced Pathophysiology

Professor’s Name

John D. Chovan, James R. Cacchillo

Keywords

Septic Shock, Organ Failure

Subject Categories

Bacterial Infections and Mycoses | Medical Pathology | Medicine and Health Sciences | Nursing

Abstract

The current definition of sepsis is suspected or documented infection plus at least one systemic manifestation of infection. Severe sepsis has been defined as sepsis plus evidence of organ dysfunction. Identifying acute organ dysfunction is a marker of severe sepsis. This topic was chosen after witnessing a number a patients fall into septic shock before severe sepsis was diagnosed and treatment initiated. Diagnosis of severe sepsis is important for specific protocol to be implemented in a timely fashion. The current differentiation between sepsis and severe sepsis is evidence of organ dysfunction. There are many examples of organ dysfunction that are not commonly considered when doing a patient workup. Increasing knowledge of acute organ dysfunction markers could potentially lead to earlier diagnosis of severe sepsis. The earlier it is diagnosed, the sooner treatment protocol can be initiated. Recent research showed that if severe sepsis is diagnosed timely, administration of timely drugs improved cardiovascular performance, lessened the inflammatory response, tissue hypo-perfusion and multi-organ injury, and most importantly reduced mortality (Lin, Lee, & Wu, 2013).

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