Undergraduate Honors Thesis Projects
Date of Award
2015
Document Type
Honors Paper
Degree Name
Biochemistry and Molecular Biology-BS
Department
Biochemistry and Molecular Biology
Advisor
John Tansey, Ph.D.
First Committee Member
John Tansey, Ph.D.
Second Committee Member
Jennifer Bennett, Ph.D.
Third Committee Member
Stephanie Patridge, Ph.D.
Keywords
Lipid Metabolism, Evolution, Bioinformatics, CGI-58, ATGL, Perilipin
Subject Categories
Bioinformatics | Other Biochemistry, Biophysics, and Structural Biology
Abstract
Lipolysis is a conserved pathway used by organisms for the mobilization of fatty acid (FA) out of triacylglycerol (TAG). Neutral lipids are stored in lipid-storage droplets (LSD) which are in nearly every cell of an organism. LSDs are the location of lipolysis. Perilipin proteins are lipid-droplet associated proteins. Perilipins interact with other proteins such as ATGL that breaks down TAG into FA and DAG. Because of its conservation as a whole system, this suggests that proteins of the same pathway are evolving together. This present study traces the evolutionary history of lipolysis-related proteins amongst individual organisms and classes of organisms to look at the conservation of relationship between the proteins.
Recommended Citation
Bowman, Jacob D., "Conservation of Lipid Storage Droplet Proteins in Evolution of Animalia" (2015). Undergraduate Honors Thesis Projects. 25.
https://digitalcommons.otterbein.edu/stu_honor/25