Date Written

2016

Document Type

Distinction Paper

Degree Name

Equine Pre-Veterinary/Pre-Graduate Studies-BS

Department

Chemistry

Advisor

Dr. Robin Grote

First Committee Member

Dr. Robin Grote

Second Committee Member

Dr. Steffanie Burk

Third Committee Member

Dr. Jeffrey Lehman

Keywords

Heterocycles, Oxadiazoles, Biofilm Inhibition

Subject Categories

Biological Factors | Heterocyclic Compounds | Pharmaceutical Preparations

Abstract

The objective of this study was to observe how heterocyclic molecules could be synthesized and if they were reproducible at high yields to create 1,3,4-oxadiazoles. This work specifically observed how the non-benzoic acid derivatives reacted with the hydrazide starting material and if the molecules changed structurally. The cyclodehydration reaction used trimethyldibromo phosphorane as a reagent, which was proven to be successful in a previous study at producing 1,3,4-oxadiazoles. Those products were used to determine if the added substituents affected the percent yield and the general reproducibility of the desired molecules. All of the non-benzoic acid derivatives used in this study were successful reproducing final products under the specified conditions. The second part of this study was to apply previously derived compounds into a practical use by growing cultures and determining how affective the compounds were against biofilm productions. The study utilized treated tissue cultured plates using Streptomyces coelicolor wild-type as the bacteria to determine if the compounds were successful in inhibiting biofilm growth. After further analysis of the plates, none of the compounds that were used showed to be inhibitors for biofilm growth. Compound 3 showed promising results but would require further analysis to determine if the compound could be capable of biofilm inhibition.

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